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Moreover, trimethoprim is more rapidlyabsorbed than sulfamethoxazole—concentrationratios may vary with time. In arandomized trial, the effects of conivaptan were assessed inhyponatremic hospitalized patients.55 In this trial, 84 patientswere randomized either to receive intravenous conivaptan (20 mgloading dose followed by 40 or 80 mg infusion for 96 hours) orplacebo.

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Acute side effects and complicationsafter short-term preoperative radiotherapy combined with total mesorectal excision inprimary rectal cancer: Report of a multicenter randomized trial.

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